To develop and validate a micro-ultrasound risk score that predicts the likelihood of significant prostate cancer in the anterior zone.
Patients were enrolled from three expert institutions familiar with micro-ultrasound. The study was conducted in two phases. First, the PRI-MUS anterior score was developed by assessing selected prostate videos from patients who subsequently underwent radical prostatectomy. Second, seven urology readers with varying levels of experience in micro-ultrasound examination evaluated prostate loops according to the PRI-MUS anterior score. Each reader watched the videos and recorded the likelihood of the presence of significant cancer in the anterior part of the prostate in a three-point scale. The coherence among the readers was calculated using the Fleiss kappa and the Cronbach alpha.
A total of 102 selected prostate scans were used to develop the risk assessment for anterior zone cancer in the prostate. The score comprised three categories: likely, equivocal, and unlikely. The median (IQR) sensitivity, specificity, positive predictive value, and negative predictive value for the seven readers were 72% (68-84), 68% (64-84), 75% (72-81), and 73% (71-80), respectively. The mean SD ROC AUC was 0.75 ± 2%, while the Fleiss kappa and the Cronbach alpha were 0.179 and 0.56, respectively.
Micro-ultrasound can detect cancerous lesions in the anterior part of the prostate. When combined with the PRI-MUS protocol to assess the peripheral part, it enables an assessment of the entire prostate gland. Pending external validation, the PRI-MUS anterior score developed in this study might be implemented in clinical practice.
World journal of urology. 2023 Sep 15 [Epub ahead of print]
Sandy Schaer, Arnas Rakauskas, Julien Dagher, Stefano La Rosa, Jake Pensa, Wayne Brisbane, Leonard Marks, Adam Kinnaird, Robert Abouassaly, Eric Klein, Lewis Thomas, Jean-Yves Meuwly, Pamela Parker, Beat Roth, Massimo Valerio
Unit of Urology, Department of Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland. ., Unit of Urology, Department of Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland., Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., UCLA Institute of Urologic Oncology, Los Angeles, USA., Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, USA., Department of Radiology, Lausanne University Hospital (CHUC), Lausanne, Switzerland., Department of Radiology, Hull University Teaching Hospitals NHS Trust, Hull, UK.