To investigate the effect of androgen deprivation therapy (ADT) on health-related quality of life (HRQOL) in Asian men with all stages of prostate cancer.
READT (real-life evaluation of the effect of ADT in prostate cancer patients in Asia) was a multi-center, prospective observational study involving six sites across four Asian populations. We enrolled eligible prostate cancer patients, who opted for ADT alone or in combination without prior neoadjuvant or adjuvant ADT within 12 months. The EuroQoL-5 dimensions, 5 level scale (EQ-5D-5L) utility index scores and visual analog scale (VAS) were evaluated at baseline, month 6 and month 12.
A total of 504 patients were recruited into READT between September 2016 and May 2020 with 52.9% diagnosed with metastatic prostate cancer. The EQ-5D-5L was evaluable in 442/504 (87.7%) of patients. Overall baseline EQ-5D-5L utility index score was 0.924 (interquartile range [IQR] 0.876-1.000). We observed a statistically significant difference in baseline EQ-5D-5L utility index score among different populations with a median EQ-5D-5L utility index score of 1 for Taiwan & Hong Kong, 0.897 for China and 0.838 for Malaysia. Similar trend was observed throughout multiple treatment time-points. Stage IV prostate cancer were significantly associated with a lower baseline EQ-5D-5L utility index score compared to stage I-III prostate cancer, producing a median disutility value of -0.080. Participants had a high median VAS (80, IQR 70-90), indicating good overall health on average during ADT initiation.
The study highlights the differences in health state utility index scores among various Asian prostate cancer patients receiving ADT at real-world setting. Our findings will be informative and useful in cost-effectiveness evaluation and policy decision making.
The world journal of men's health. 2023 Oct 11 [Epub ahead of print]
Jasmine Lim, Chi-Fai Ng, Yong Wei, Teng Aik Ong, Peggy Sau-Kwan Chu, Wayne Kwun Wai Chan, Chao Yuan Huang, Kuo-Kang Feng, Jeremy Yuen-Chun Teoh, Ning Xu, Jer Wei Low, Wei Sien Yeoh, Peter Ka-Fung Chiu, Chi-Hang Yee, Steven Chi Ho Leung
Urology Unit, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Department of Surgery, SH Ho Urology Centre, The Chinese University of Hong Kong, Hong Kong, China. ., Department of Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China., Urology Unit, Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. ., Division of Urology, Tuen Mun Hospital, Hong Kong, China., Division of Urology, Kwong Wah Hospital, Hong Kong, China., Department of Urology, National Taiwan University Hospital, Taipei, Taiwan., Department of Surgery, SH Ho Urology Centre, The Chinese University of Hong Kong, Hong Kong, China.