To compare characteristics and outcomes in patients who had radiotherapy (RT) for prostate cancer (PCa) and underwent urinary diversion (UD) due to prostatic fistula (Fistula) vs. localized radiation injury (Localized).
This study was a retrospective single-institution study. Exclusion criteria included: follow-up < 3 months, large pelvic tumor, and surgery for cancer control. The Fistula group included fistulization outside of the urinary tract (rectal, soft tissue, thigh, pubic symphysis, and extensive necrosis surrounding the prostate). The group Localized had a multitude of problems; however, all were confined to the urinary tract. Patient characteristics, perioperative variables, and outcomes were compared between groups.
69 patients were included and had UD from 2009-2022. Median age and time from RT to UD were 73 (IQR-67.9,78.1) and 7.3 (IQR-3.2,12.5) years. There were 29 (42%) and 40 (58%) patients in the Fistula and Localized groups. The Fistula group had a higher rate of abdominal/perineal approach (62.1% vs. 12.5%,p<0.001), a lower rate of right colon pouch (17.2% vs. 40%,p=0.043), and a longer operative time (515.7 vs 414.2 mins,p=0.017). Clavien-Dindo complications ≥ 3 were higher in the Fistula group (44.8% vs. 20%,p=0.027), including a higher rate of re-operation for recurrent pelvic abscess (37.9% vs. 5%,p<0.001). Survival for the cohort was 85.5% and did not differ between groups.
Patients with prostate fistula after RT for PCa undergoing UD had longer, more complex operations, and higher rates of complications, notably post-operative pelvic abscesses, compared to men with localized RT injury. Long-term survival was comparable in both groups.
Urology. 2023 Nov 29 [Epub ahead of print]
Jeremy B Myers, Beatriz S Hernandez, Benjamin McCormick, Joemy Ramsay, John D Kriesel, Kevin J Hebert, Kiarad Fendereski
University of Utah Department of Surgery (Urology), Salt Lake City, Utah., University of Utah Department of Internal Medicine (Infectious Disease), Salt Lake City, Utah.