Patient-derived xenografts (PDXs) are generated by engrafting human tumours into mice. Serially transplantable PDXs are used to study tumour biology and test therapeutics, linking the laboratory to the clinic. Although few prostate cancer PDXs are available in large repositories, over 330 prostate cancer PDXs have been established, spanning broad clinical stages, genotypes and phenotypes. Nevertheless, more PDXs are needed to reflect patient diversity, and to study new treatments and emerging mechanisms of resistance. We can maximize the use of PDXs by exchanging models and datasets, and by depositing PDXs into biorepositories, but we must address the impediments to accessing PDXs, such as institutional, ethical and legal agreements. Through collaboration, researchers will gain greater access to PDXs representing diverse features of prostate cancer.
Nature reviews. Urology. 2023 Jan 17 [Epub]
Mitchell G Lawrence, Renea A Taylor, Georgia B Cuffe, Lisa S Ang, Ashlee K Clark, David L Goode, Laura H Porter, Clémentine Le Magnen, Nora M Navone, Jack A Schalken, Yuzhuo Wang, Wytske M van Weerden, Eva Corey, John T Isaacs, Peter S Nelson, Gail P Risbridger
Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia. ., Melbourne Urological Research Alliance, Monash Biomedicine Discovery Institute, Clayton, Victoria, Australia., Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia., Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands., Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Department of Urology, Erasmus MC Cancer Institute, Rotterdam, Netherlands., Department of Urology, University of Washington, Seattle, WA, USA., Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, USA., Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia. .