Outcomes after Localized Prostate Cancer TreatmentDonovan et al. present the long-term patient-reported outcomes of 1643 randomly assigned participants in the ProtecT (Prostate Testing for Cancer and Treatment) trial. Functional and quality-of-life impacts of prostatectomy, radiotherapy with neoadjuvant androgen deprivation, and active monitoring are described. Over the trial period from 7 to 12 years, generic quality-of-life scores were similar among all groups, with varying degrees of impact on urinary leakage, sexual function, and fecal leakage depending on the treatment group.
NEJM evidence. 2023 Mar 11 [Epub]
Jenny L Donovan, Freddie C Hamdy, J Athene Lane, Grace J Young, Chris Metcalfe, Eleanor I Walsh, Michael Davis, Thomas Steuart-Feilding, Jane M Blazeby, Kerry N L Avery, Richard M Martin, Prasad Bollina, Andrew Doble, Alan Doherty, David Gillatt, Vincent Gnanapragasam, Owen Hughes, Roger Kockelbergh, Howard Kynaston, Alan Paul, Edgar Paez, Phillip Powell, Derek J Rosario, Edward Rowe, Malcolm Mason, James W F Catto, Tim J Peters, Julia Wade, Emma L Turner, Naomi J Williams, Jon Oxley, John Staffurth, Richard J Bryant, David E Neal
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom., Department of Urology and Surgery, Western General Hospital, University of Edinburgh, United Kingdom., Department of Urology, Addenbrooke's Hospital, Cambridge, United Kingdom., Department of Urology, Queen Elizabeth Hospital, Birmingham, United Kingdom., Department of Urological Oncology and Robotic Surgery, Macquarie University, Sydney., Division of Urology, Department of Surgery and Cambridge Urology Translational Research and Clinical Trials Office, Cambridge, United Kingdom., Department of Urology, Cardiff and Vale University Health Board, Cardiff, United Kingdom., Department of Urology, University Hospitals of Leicester, Leicester, United Kingdom., Department of Urology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom., Department of Urology, Freeman Hospital, Newcastle upon Tyne, United Kingdom., Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom., Department of Urology, Southmead Hospital and Bristol Urological Institute, Bristol, United Kingdom., School of Medicine, Cardiff University, Cardiff, United Kingdom., Department of Cellular Pathology, North Bristol NHS Trust, Bristol, United Kingdom., Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.