Meta-Analysis of Surrogate End Points in Prostate CancerGharzai et al. report on the results of a meta-analysis, which concludes that unlike the case in localized prostate cancer, surrogate end points in advanced prostate cancer may not track overall survival.
NEJM evidence. 2023 Mar 27 [Epub]
Laila A Gharzai, Ralph Jiang, Elizabeth M Jaworski, Krystal Morales Rivera, Robert T Dess, William C Jackson, Holly E Hartman, Rohit Mehra, Amar U Kishan, Abhishek A Solanki, Edward M Schaeffer, Felix Y Feng, Nicholas G Zaorsky, Alejandro Berlin, Lee Ponsky, Jonathan Shoag, Yilun Sun, Matthew J Schipper, Jorge Garcia, Daniel E Spratt
Department of Radiation Oncology, Northwestern University, Chicago., Department of Biostatistics, University of Michigan, Ann Arbor., Department of Radiation Oncology, University of Michigan, Ann Arbor., Department of Population and Quantitative Health Sciences, Case Western Reserve, Cleveland, OH., Department of Pathology, University of Michigan, Ann Arbor., Department of Radiation Oncology, University of California, Los Angeles, Los Angeles., Department of Radiation Oncology, Stritch School of Medicine, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL., Department of Urology, Northwestern University, Chicago., Department of Radiation Oncology, University of California, San Francisco, San Francisco., Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve, Cleveland, OH., Department of Radiation Oncology, University of Toronto; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON., Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve, Cleveland, OH., Department of Medicine, University Hospitals Seidman Cancer Center, Case Western Reserve, Cleveland, OH.