Predictive Model for Hormone Therapy in Prostate CancerDigital pathology images and clinical data from pretreatment prostate tissue were used to generate a predictive model to determine patients who would benefit from androgen deprivation therapy (ADT). In model-positive patients, ADT significantly reduced the risk of distant metastasis compared with radiotherapy alone.
NEJM evidence. 2023 Jun 29 [Epub]
Daniel E Spratt, Siyi Tang, Yilun Sun, Huei-Chung Huang, Emmalyn Chen, Osama Mohamad, Andrew J Armstrong, Jonathan D Tward, Paul L Nguyen, Joshua M Lang, Jingbin Zhang, Akinori Mitani, Jeffry P Simko, Sandy DeVries, Douwe van der Wal, Hans Pinckaers, Jedidiah M Monson, Holly A Campbell, James Wallace, Michelle J Ferguson, Jean-Paul Bahary, Edward M Schaeffer, Howard M Sandler, Phuoc T Tran, Joseph P Rodgers, Andre Esteva, Rikiya Yamashita, Felix Y Feng
Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland., Department of Electrical Engineering, Stanford University, Stanford, CA., Artera, Inc., Los Altos, CA., Department of Radiation Oncology, University of California, San Francisco, San Francisco., Duke Cancer Institute Center for Prostate and Urologic Cancer, Division of Medical Oncology, Department of Medicine, Duke University, Durham, NC., Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City., Department of Radiation Oncology, Dana-Farber/Brigham Cancer Center, Boston., Division of Hematology/Medical Oncology, University of Wisconsin, Madison, WI., NRG Oncology Biospecimen Bank, University of California, San Francisco, San Francisco., Department of Radiation Oncology, Saint Agnes Medical Center, Fresno, CA., Department of Radiation Oncology, Saint John Regional Hospital, Saint John, NB, Canada., University of Chicago Medicine Medical Group, Chicago., Department of Radiation Oncology, Allan Blair Cancer Centre, Regina, SK, Canada., Department of Radiation Oncology, Centre Hospitalier de l'Universite de Montreal, Montreal., Department of Urology, Northwestern University Feinberg School of Medicine, Chicago., Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles., Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore., Statistics and Data Management Center, NRG Oncology, Philadelphia.