To promote comprehensive care of patients throughout the androgen deprivation therapy (ADT) prescribing process, the Prostate Cancer 360 (PC360) Working Group developed monitoring and management recommendations intended to mitigate or prevent ADT-associated adverse events.
The PC360 Working Group included 14 interdisciplinary experts with a dedicated clinical interest in prostate cancer and ADT management. The working group defined challenges associated with ADT adverse event management and then collaboratively developed comprehensive care recommendations intended to be practical for ADT prescribers.
The PC360 Working Group developed both overarching recommendations for ADT adverse event management and specific recommendations across 5 domains (cardiometabolic, bone, sexual, psychological, and lifestyle). The working group recommends an interdisciplinary, team-based approach wherein the ADT prescriber retains an oversight role for ADT management while empowering patients and their primary and specialty care providers to manage risk factors. The PC360 recommendations also emphasize the importance of proactive patient education that involves partners or other support providers. Recommended monitoring and assessment tools, risk factor management, and patient counseling points are also included for the 5 identified domains, with an emphasis on lifestyle and behavioral interventions that can improve quality of life and reduce the risk for ADT-associated complications.
Comprehensive care of patients receiving ADT requires early and ongoing coordinated management of a variety of health domains, including cardiometabolic, bone, sexual, psychological health. Patient education and primary care provider involvement should begin prior to ADT initiation and continue throughout treatment to improve patient and partner quality of life.
Urology practice. 2023 Nov 02 [Epub]
E David Crawford, Marc B Garnick, Robert H Eckel, Martin M Miner, Stephen J Freedland, Russell K Pachynski, Richard J Wassersug, Matthew T Rosenberg, Lauren M Walker, Ciaran Fairman, Tracy Curley, Michael Crosby, Pao-Hwa Lin, Jason M Hafron
Department of Urology, University of California San Diego, La Jolla, California., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts., Division of Endocrinology, Metabolism and Diabetes, Anschutz Medical Center, University of Colorado, Denver, Aurora, Colorado., Warren Alpert School of Medicine, Brown University, Providence, Rhode Island., Center for Integrated Research in Cancer and Lifestyle, Cedars-Sinai Medical Center, Los Angeles, California., Division of Oncology, Washington University School of Medicine, St Louis, Missouri., University of British Columbia, Vancouver, British Columbia, Canada., Mid-Michigan Health Centers, Jackson, Michigan., Department of Oncology, Department of Psychology, University of Calgary, Calgary, Alberta, Canada., Department of Exercise, University of South Carolina, Columbia, South Carolina., Memorial Sloan-Kettering Cancer Center, New York, New York., Veterans Prostate Cancer Awareness Inc, San Diego, California., Department of Medicine, Duke University School of Medicine, Durham, North Carolina., Michigan Institute of Urology, West Bloomfield, Michigan.