To determine the rate and time of testosterone (T) recovery in patients (pts) with localised prostate cancer treated with radiotherapy plus 0-, 6-, 18- or 36-month of androgen deprivation therapy (ADT).
In 1230 pts with prostate cancer randomised into two phase III trials, serum T was measured at baseline, then regularly. T recovery rate was compared between normal vs. abnormal baseline T and with ADT duration with Chi-square test or Fisher's exact test. A multivariable logistic regression model to predict the probability of recovering normal T was performed.
Overall, 87.4 % (167/191), 75.9 % (293/386), 54.8 % (181/330) and 43.2 % (80/185) of pts, recovered normal T on the 0-, 6-, 18- or 36-month schedule, respectively (p < 0.001). In patients recovering normal T, the median time to T recovery increased with ADT duration ranging from 0.31, 1.64, 3.06 to 5.0 years for the 0-, 6-, 18- or 36-month schedules, respectively (p < 0.001) and was significantly faster for those with a normal T at baseline (p < 0.001). On multivariable analysis, older age and longer ADT duration are associated with a lower T recovery.
Testosterone recovery rate after ADT depends on several factors including hormonal duration, normal baseline T, age and medical comorbidities. A longer ADT duration is the most important variable affecting T recovery. The data from this report might be a valuable tool to help physicians and patients in evaluating risks and benefits of ADT.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2024 Mar 27 [Epub ahead of print]
Abdenour Nabid, Nathalie Carrier, André-Guy Martin, Eric Vigneault, Jean-Paul Bahary, Thu Van Nguyen, Peter Vavassis, Sylvie Vass, Marc-André Brassard, Boris Bahoric, Robert Archambault, François Vincent, Redouane Bettahar, Marie Duclos, Derek Wilke, Luis Souhami
Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada. Electronic address: ., Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada., Centre Hospitalier Universitaire de Québec, Québec, Canada., Centre Hospitalier Universitaire de Montréal, Montréal, Canada., Hôpital Maisonneuve-Rosemont de Montréal, Montréal, Canada., Centre de Santé et Services Sociaux de Chicoutimi, Chicoutimi, Canada., Hôpital Général Juif de Montréal, Montréal, Canada., Hôpital de Gatineau, Gatineau, Canada., Centre Hospitalier Régional de Trois-Rivières, Trois-Rivières, Canada., Centre Hospitalier Régional de Rimouski, Rimouski, Canada., McGill University Health Centre, Montréal, Canada., Nova Scotia Cancer Center, Halifax, Canada.