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Physician Perspectives on the Nonclinical Factors That Contribute to Decision-Making for Advanced Prostate Cancer Care: A Qualitative Study

Introduction: Promising new treatments exist for advanced prostate cancer. Decision-making is complicated: there are minimal comparative effectiveness data; differing routes of administration, drug mechanisms of action, and side effects; and significant price differences. These challenges contribute to variations in care and quality, treatment disparities, and lack of concordance with patient values. The aim of this study was to examine physician perspectives of factors influencing decision-making for first-line advanced prostate cancer treatments.

Methods: We conducted a qualitative descriptive study of physicians who treat patients with advanced prostate cancer from September 2021 to June 2022. Participants were purposively sampled from across the United States.

Results: Twenty-seven physicians participated. We identified 17 domains and three overarching themes affecting physician decision-making for advanced prostate cancer care. The themes were as follows: (1) physician and practice factors affect prescribing decisions, (2) health practice resource availability affects the likelihood that patients will receive the recommended treatment and that the treatment will be in-line with patients' values, and (3) patient nonclinical factors influence physician decision-making, but patient values could be better incorporated into prescribing decisions. Based on the analyses, we constructed a preliminary framework of clinician decision-making for advanced prostate cancer.

Conclusions: Physicians perceive that nonclinical patient, physician, and practice factors affect decision-making. These factors, therefore, must be considered when implementing programs to optimize a physician's ability to provide quality cancer care, reduce health care disparities and patient financial burden, and provide patient goal concordant care. The preliminary theoretical model of clinician decision-making for advanced prostate cancer care may also be used to inform these efforts.

Kaye, Deborah R.1,2,3,4 Tu, Karissa5 Davis, J. Kelly6 Campagna, Ada6 Docherty, Sharron L.7 Kurnot, Jeremy1 Zhang, Tian8 George, Daniel J.3,9 Ubel, Peter A.2,6

  1. Department of Urology, Duke University, Durham, North Carolina
  2. Duke-Margolis Center for Public Policy, Duke University, Durham, North Carolina
  3. Duke Cancer Institute, Duke University, Durham, North Carolina
  4. Duke Clinical Research Institute, Duke University, Durham, North Carolina
  5. School of Medicine, University of Washington, Seattle, Washington
  6. Fuqua School of Business, Duke University, Durham, North Carolina
  7. School of Nursing, Duke University, Durham, North Carolina
  8. Division of Medical Oncology, Department of Medicine, University of Texas Southwestern, Dallas, Texas
  9. Division of Medical Oncology, Department of Medicine, Duke University, Durham, North Carolina
Source: Kaye D, Tu K, Davis K, et al. Physician Perspectives on the Nonclinical Factors That Contribute to Decision-Making for Advanced Prostate Cancer Care: A Qualitative Study. JU Open Plus 2(3):e00014, March 2024. | DOI: 10.1097/JU9.0000000000000118.