The aim of this article was to offer a comprehensive non-systematic review of the literature about the use of Nuclear Medicine imaging exams for the evaluation of prostate cancer (PCa) in the recurrent setting, with a particular regard to positron emission tomography/computed tomography (PET/CT) imaging.
A comprehensive nonsystematic literature review was performed in March 2024. Literature search was updated until March 2024. The most relevant studies have been summarized, giving priority to registered clinical trials and multicenter collaborations.
Restaging BCR with advanced Nuclear Medicine Imaging, such as prostate-specific membrane antigen-PET/CT could lead to stage migration and pave the way for additional management strategies, such as stereotactic ablative radiotherapy in patients with low-burden or oligometastatic disease, potentially delaying the need of systemic therapies. While OS benefits of targeting PET/CT positive disease are still lacking, data on progression- and metastasis-free-survival are emerging. Improvements in quality-of-life assessments are already evident.
PCa is one of the most common malignancy in men. In the last 10 years PCa imaging has become significantly more accurate and is now essential for the definition of the extent of the disease in different phases of its natural history. This opened the road to novel management strategies, especially in the recurrent setting, in which the oligometastatic state is now being explored in several trials regarding the prognostic significance of metastasis directed therapies aimed at personalizing the treatment for every single patient.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2024 Jun [Epub]
Lorenzo Muraglia, Egesta Lopci, Jelena Jandric, Roberta Zanca, Marcello Rodari, Matteo Perrino, Raffaella Lucchini, Davide Baldaccini, Francesco Ceci, Laura Evangelista
Department of Nuclear Medicine, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy - ., Department of Nuclear Medicine, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy., Department of Oncology, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy., Department of Radiation Oncology, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy., Department of Nuclear Medicine, European Institute of Oncology IRCCS, Milan, Italy.