Management of de novo Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) and the role of Radiotherapy: A Consensus by the Italian Association of Radiotherapy and Clinical Oncology (AIRO).

Prostate cancer treatments paradigms are in continuous evolution, especially in metastatic setting. In this context, the Genito-Urinary (GU) Group of Italian Association of Radiotherapy and Clinical Oncology (AIRO) aimed to create a Consensus on radiotherapy indication in de novo metastatic hormone sensitive prostate cancer both on primary tumour and metastatic sites.

A panel of experts, involved in clinical management of prostate cancer, through the estimate-talk-estimate (ETE) method, developed a list of items and correspondent statements on the identified topic.

Seven conclusive items were identified with 12 statements about the chosen topic, radiotherapy in metastatic hormone sensitive prostate cancer on primary tumour and metastatic sites.

This consensus might help clinicians in prostate cancer managing in daily clinical practice.

Practical radiation oncology. 2024 Oct 26 [Epub ahead of print]

Andrea Lancia, Anna Rita Alitto, Giovanni Pappagallo, Elisa Ciurlia, Giulio Francolini, Rolando D'Angelillo, Sergio Fersino, Niccolò Giaj Levra, Barbara Alicja Jereczek-Fossa, Alessandro Magli, Francesco Pasqualetti, Alessia Reali, Corrado Spatola, Luca Triggiani

Department of Radiation Oncology, Policlinico San Matteo Pavia Fondazione IRCCS, Pavia, Italy. Electronic address: ., UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy., School of Methodology of Clinical Research, IRCCS "Sacro Cuore-Don Calabria" Hospital, 37024 Negrar di Valpolicella, VR, Italy., Department of Radiation Therapy, "Vito Fazzi" Hospital, 73100 Lecce, Italy., Radiation Oncology Unit, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy., Radiotherapy, Department of Oncoematology, Policlinico Tor Vergata, 00133 Rome, Italy., Department of Radiation Therapy, S.Chiara Hospital, Trento., Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don-Calabria, Negrar di Valpolicella, Italy., Division of Radiation Oncology, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Department of Radiation Therapy, AULSS1-Dolomiti, S.Martino Hospital, Belluno., Department of Radiation Oncology, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Tuscany, Italy., Radiation Oncology Department, Michele e Pietro Ferrero Hospital, Verduno., Radiation Oncology Unit, Department of Medical Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, 95123 Catania, Italy., Radiation Oncology Unit, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.