WASHINGTON, DC USA (UroToday.com) - This study has made an important link between smoking and prostate cancer.
They report that smoking is associated with adverse pathologic features and a higher risk of biochemical recurrence in men undergoing radical prostatectomy. They studied 630 men with smoking data that underwent radical prostatectomy between 1989-2005. There were 321 smokers and 309 nonsmokers. Pathologic outcomes included prostate weight, volume of cancer, volume of high-grade cancer, margin status, seminal vesicle involvement, extraprostatic extension, perineural invasion, angiolymphatic invasion, and the presence of nodal metastasis. They defined biochemical recurrence as a postoperative PSA>0.2 ng/ml. Univariate analysis and multivariate linear and Cox regression were used to study the impact of smoking on these outcomes.
They reported that the volume of cancer (2.54 vs. 2.16 mL, p=0.016) and the volume of high-grade cancer (0.58 vs. 0.28 mL, p=0.004) was greater in smokers vs. nonsmokers. Smoking independently predicted greater volumes of cancer and high-grade cancer in multivariate analysis. Heavy smokers (defined as >20 pack-year history) had a greater risk of biochemical recurrence on univariate survival analysis. Smoking also predicted a greater risk of biochemical recurrence on Cox regression, the magnitude of which was approximately 1% per pack-year smoked. These data, if confirmed, will need to potentially be considered in assessing prostate cancer patient risk.
Presented by Tin Ngo, et al. at the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA
Reported for UroToday by Christopher P. Evans, MD, FACS, Professor and Chairman, Department of Urology, University of California, Davis, School of Medicine.
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