Department of Radiation Oncology, Pitie-Salpetriere University Hospital, Paris, France.
To compare freedom from biochemical failure (FFBF) of French Polynesian (FP) and Native European (NE) prostate cancer patients after definitive conformal radiotherapy (RT).
Data were reviewed from medical records of 152 consecutive patients (46 FP and 106 NE) with clinically localised prostate cancer treated with definitive RT. Neoadjuvant androgen deprivation therapy (ADT) was used in 22% of cases. Definition for biochemical failure was a rise by 2ng/mL or more above the nadir prostate-specific antigen (PSA) level. The median follow-up was 34months.
In comparison to NE patients, FP patients were younger (p=0.002) with a higher low-risk proportion (p=0.06). Probability of 5-year FFBF was 77% in the NE cohort and 58.0% in the FP cohort (p=0.017). Univariate analysis showed that FP ethnicity was associated with worse prognosis in high-risk tumours (p=0.004). Cox multivariate analysis showed that factors associated with FFBF were risk category (p< 0.017), and FP origin (p=0.03), independently of ADT and radiation dose.
FP ethnicity was an independent prognostic factor for biochemical relapse after definitive conformal RT for prostate cancer.
Written by:
Levy A, Chargari C, Desrez G, Leroux S, Sneyd MJ, Mozer P, Comperat E, Feuvret L, Lang P, Lopez S, Assouline A, Hemery C, Mazeron JJ, Simon JM. Are you the author?
Reference: Radiother Oncol. 2011 Jun 30. Epub ahead of print.
doi: 10.1016/j.radonc.2011.05.075
PubMed Abstract
PMID: 21723636
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