Urologische Klinik, RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.
Many patients with castration-resistant prostate cancer suffer from local disease progression, mostly consisting of subvesical obstruction, gross haematuria and rectal invasion with obstructive ileus. We analysed the benefit of palliative radical surgery in this patient cohort.
Between 2004 and 2010, 20 patients underwent radical surgery; 12 patients underwent radical cystoprostatectomy, 3 patients required additional rectal resection and 4 patients were treated by radical prostatectomy. One patient with a poor prognosis received an ureterocutaneostomy and a colostomy. In all other patients an ileal conduit was chosen for urinary diversion.
The reduction of symptoms could be achieved in16 of 20 (80%) patients. The median symptom-free survival was 15.3 (6-25) months, and median survival was 20.3 (9-28) months.
With radical tumour surgery an effective local symptom control can be achieved. This individual therapeutic concept should be discussed in highly selected patients.
Article in German.
Written by:
Pfister D, Porres D, Epplen R, von Erps T, Heidenreich A. Are you the author?
Reference: Urologe A. 2011 Jul 30. Epub ahead of print.
doi: 10.1007/s00120-011-2659-7
PubMed Abstract
PMID: 21800193
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