Institut für Pathologie und Institut für Prostatakarzinom-Forschung, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland.
For many tumors the early detection of precursor lesions of invasive cancer has an impact on the clinical course. The high-grade prostatic intraepithelial neoplasia (HG-PIN) is the only accepted facultative precursor lesion for acinar prostate cancer. While HG-PIN shows many similarities to prostate cancer it is most probably not a precursor of every prostate cancer variant. However, the detection of HG-PIN in needle biopsies is a significant risk factor for the subsequent diagnosis of invasive prostate cancer. Low-grade PIN (LG-PIN), proliferative inflammatory atrophy (PIA), and atypical adenomatous hyperplasia are no longer considered to be true precursor lesions.
Article in German.
Written by:
Braun M, Perner S. Are you the author?
Reference: Pathologe. 2011 Aug 17. Epub ahead of print.
doi: 10.1007/s00292-011-1500-9
PubMed Abstract
PMID: 21845356
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