Kontinenzzentrum, Urologische Klinik, RWTH, Universitätsklinikum Aachen, Pauwelsstraße 30, 52057, Aachen, Deutschland.
The aim of this prospective study was to investigate factors influencing long-term health-related quality of life (HRQoL) in patients treated for prostate cancer with no signs of tumor relapse.
We included epidemiological and oncological data as well as standardized questionnaires on incontinence and sexual function. Data were analyzed using standard descriptive and explorative statistics.
We obtained pre-therapeutic data as well as a complete data set after 36 months for 488 patients. A total of 162 patients (33.2%) in whom we could not exclude a tumor relapse according to the guidelines of the EAU or because of incomplete data were excluded from further analysis. In a univariate analysis as expected stress incontinence, lower urinary tract symptoms (LUTS), overactive bladder (OAB), urgency, pad use, sexual activity as well as perceived pre-therapeutic HRQoL, being privately insured, and a better school education were significantly associated with post-therapeutic long-term HRQoL (p< 0.05). In a multivariate analysis of covariance only dry OAB (p=0.0411) and sexual activity (p=0.0046) proved to be independent parameters with a significant impact on HRQoL after 36 months.
Symptoms of OAB even without urine loss after successful treatment of prostate cancer need to be addressed in clinical practice as well as in research studies.
Article in German.
Written by:
Kirschner-Hermanns R, Klementz T, Haselhuhn A, Jakse G, Heidenreich A, Brehmer B. Are you the author?
Reference: Urologe A. 2011 Sep 18. Epub ahead of print.
doi: 10.1007/s00120-011-2709-1
PubMed Abstract
PMID: 21927876
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