Spinal and bulbar muscular atrophy (SBMA) is a hereditary motor neuron disease caused by the expansion of CAG triplets in the androgen receptor (AR).
Since the length of CAG repeat is inversely related with AR function, patients with a longer CAG repeat are expected to have a lower incidence of prostate cancer (PCa). Here we report an extremely rare case of high stage prostate cancer in patient with SBMA, which responded to maximal androgen blockade therapy.
Written by:
Kosaka T, Miyajima A, Kikuchi E, Takahashi S, Suzuki N, Oya M. Are you the author?
Reference: J Androl. 2011 Sep 22. Epub ahead of print.
PubMed Abstract
PMID: 21940987
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