Departments of Clinical Medicine and Prevention, Centre of Biostatistics for Clinical Epidemiology bStatistics, University of Milano-Bicocca, Milan, Italy.
Statistics, University of Milano-Bicocca; Department of Epidemiology, Mario Negri Institute for Pharmacological Research; Department of Occupational Health, University of Milano; Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy; International Agency for Research on Cancer; International Prevention Research Institute, Lyon, France; Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Inconsistent results on the relationship between alcohol drinking and prostate cancer have been found. In order to provide a definite quantification of the dose-risk relation, we investigated the risk of prostate cancer at different levels of alcohol consumption, by conducting a meta-analysis of epidemiological studies. We performed a literature search using PubMed of all case-control and cohort studies published as original articles in English up to December 2010. We identified 50 case-control and 22 cohort studies, including a total of 52 899 prostate cancer cases. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates. We performed a dose-risk analysis using nonlinear random-effects meta-regression models. The overall relative risk for any alcohol drinking compared with non/occasional drinking was 1.06 [95% confidence interval (CI), 1.01-1.10]. The relative risks were 1.05 (95% CI, 1.02-1.08), 1.06 (95% CI, 1.01-1.11), and 1.08 (95% CI, 0.97-1.20) for light (≤ 1 drink/day), moderate (>1 to < 4 drinks/day), and heavy alcohol drinking (≥4 drinks/day), respectively. This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and prostate cancer, even at high doses.
Written by:
Rota M, Scotti L, Turati F, Tramacere I, Islami F, Bellocco R, Negri E, Corrao G, Boffetta P, La Vecchia C, Bagnardi V. Are you the author?
Reference: Eur J Cancer Prev. 2011 Nov 15. Epub ahead of print.
doi: 10.1097/CEJ.0b013e32834dbc11
PubMed Abstract
PMID: 22095143
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