METHODS: Sixteen men with a diagnosis of metastatic prostate cancer to bones were examined with DCE-MRI at 1.5 Tesla. The mean contrast agent concentration vs time curves for bone metastasis and normal bone were calculated and Ktrans and ve values were estimated and compared.
RESULTS: An early significant enhancement (wash-out: n = 6, plateau: n = 8 and persistent: n = 2) was detected in all bone metastases (n = 16). Bone metastasis from prostate cancer showed significant enhancement and high Ktrans and ve values compared to normal bone which does not enhance in the elderly population. The mean Ktrans was 0.101/min and 0.0051/min (P < 0.001), the mean ve was 0.141 and 0.0038 (P < 0.001), for bone metastases and normal bone, respectively.
CONCLUSION: DCE-MRI and its quantitative perfusion parameters may have a role in improving the detection of skeletal metastasis in prostate cancer patients.
Written by:
Kayhan A, Yang C, Soylu FN, Lakadamyalı H, Sethi I, Karczmar G, Stadler W, Oto A. Are you the author?
Department of Radiology, University of Chicago, Chicago, IL 60637, United States.
Reference: World J Radiol. 2011 Oct 28;3(10):241-5.
doi: 10.4329/wjr.v3.i10.241
PubMed Abstract
PMID: 22229077
UroToday.com Prostate Cancer Section
