Prostate cancer (PC) remains a cause of death worldwide.
Here we investigate whether a single microfocus of PC at the biopsy (graded as Gleason 6 or less, ≤ 5% occupancy) and the PSA < 10 ng/mL can define the archetype of low-risk prostate disease. 4500 consecutive patients were enrolled. Among them, 134 patients with a single micro-focus of PC were followed up, and the parameters influencing the biochemical relapse (BR) were analysed. Out of 134 patients, 94 had clinically significant disease, specifically in 74.26% of the patients with PSA < 10 ng/mL. Positive surgical margins and the extracapsular invasion were found in 29.1% and 51.4% patients, respectively. BR was observed in 29.6% of the patients. Cox regression evidenced a correlation between the BR and Gleason grade at the retropubic radical prostatectomy (RRP), capsular invasion, and the presence of positive surgical margins. Multivariate regression analysis showed a statistically significant correlation between the presence of surgical margins at the RRP and BR. Considering a single micro-focus of PC at the biopsy and PSA serum level < 10 ng/mL, clinically significant disease was found in 74.26% patients and only positive surgical margins are useful for predicting the BR.
Written by:
Taverna G, Benecchi L, Grizzi F, Seveso M, Giusti G, Piccinelli A, Benetti A, Colombo P, Minuti F, Graziotti P. Are you the author?
Department of Urology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy.
Reference: J Oncol. 2012;2012:645146.
doi: 10.1155/2012/645146
PubMed Abstract
PMID: 22848218
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