PURPOSE:Type 2 diabetes is associated with reduced risk of prostate cancer and low prostate-specific antigen levels for uncertain reasons.
Recently, two studies demonstrated the time course of diabetes with prostate-specific antigen levels, which would be explained by the chronic renal complication. Therefore, we conducted a retrospective study to determine whether diabetic nephropathy is associated with prostate-specific antigen levels.
METHODS AND RESULTS:Eligible patients were men aged ≥40 years, with type 2 diabetes and a recorded prostate-specific antigen level. Patients with a prior history of prostate cancer or prostatectomy or prostate-specific antigen level ≥10 ng/mL and patients with end-organ damage were excluded. Of the 247 patients included in the adjusted analysis, 51 (20.8 %) were diagnosed with diabetic nephropathy. A significant association of diabetic nephropathy with log-transformed prostate-specific antigen level was detected (Spearman's correlation coefficient -0.201, p = 0.003; adjusted for all other correlated variables) and fit into a linear regression model (B-coefficient -0.331, p = 0.003). Comparing diabetic nephropathy group with non-diabetic nephropathy group, the difference in log-transformed prostate-specific antigen levels was also significant (p = 0.002).
CONCLUSION: The results indicated that patients with diabetic nephropathy have low prostate-specific antigen levels, suggesting fewer prostate cancers being detected or fewer incidences among this group.
Written by:
Lei L, Mao Y, Meng D, Jiang Q, Jia X, Wang Y. Are you the author?
Division of Hematology and Endocrinology, Peking University Aerospace Center Hospital, No 15, Yuquan Road, Haidian District, Beijing, 100049, China.
Reference: Cancer Causes Control. 2012 Sep 2. Epub ahead of print.
doi: 10.1007/s10552-012-0056-1
PubMed Abstract
PMID: 22941713
UroToday.com Prostate Cancer Section
