PURPOSE: To evaluate apparent diffusion coefficient (ADC) value, metabolic ratio ((Cho + Cr)/Cit) and the combination of the two in identifying prostate malignant regions.
MATERIALS AND METHODS: Fifty-six consecutive patients with prostate biopsy results were retrospectively recruited in this study. Transrectal ultrasound-guided (TRUS) systemic prostate biopsies were used as a standard of reference. Mean ADC value and mean metabolic ratio (MMR) were calculated within each benign sextant region or malignant region. The efficiency of these two indices in prostate cancer (PCa) diagnosis is estimated in Fisher linear discriminant analysis (FLDA). The area under the receiver operating characteristic (ROC) curve was used to evaluate the distinguishing capacity of mean ADC, MMR, and the combination of the two in differentiating between noncancerous and cancerous cases.
RESULTS: There were significant differences for mean ADC value and MMR between malignant and benign regions. Weights of mean ADC value obtained by FLDA were much higher than those of MMR. In differentiating malignant regions, both ADC alone and combined ADC and metabolic ratio performed significantly better than MMR alone. However, accuracy improvements were not significant by using combined ADC and MMR than ADC alone.
CONCLUSION: DWI is more efficient than MR spectroscopic (MRS) in the detection of PCa in this study. Combined ADC and MMR performed significantly better than MMR alone in distinguishing malignant from benign region in prostate peripheral zone.
Written by:
Li B, Cai W, Lv D, Guo X, Wang X, Zhang J, Fang J. Are you the author?
College of Engineering, Peking University, Beijing, China, People's Republic of China.
Reference: J Magn Reson Imaging. 2012 Sep 21. Epub ahead of print.
doi: 10.1002/jmri.23809
PubMed Abstract
PMID: 23002033
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