PURPOSE: Evaluate outcomes and prognostic factors in men with localized prostate cancer.
METHODS AND MATERIALS: A total of 3760 patients have undergone prostate seed implantation at our institution. This review is of our initial 304 consecutive patients treated before January 30, 2001. A total of 124 patients were treated with (125)I implant monotherapy and 180 with (103)Pd implant combined with 45-Gy external beam radiation therapy.
RESULTS: The median followup was 10.3 years. A 10-year biochemical control for low risk (LR) was 98% , intermediate risk (IR) 94%, high risk (HR) 78%, and HR with one HR factor 88% (p < 0.001); cause-specific survival was 99%, 98%, and 84% for LR, IR, and HR, respectively (p < 0.001); No significant difference in outcome was seen for LR and IR patients (p > 0.3). On multivariate analysis, only pretreatment PSA, Gleason score, and T-stage were significant for biochemical control. Most biochemical failures occurred within 5 years (93%).
CONCLUSIONS: With a minimum followup of 10 years, results are excellent and do not differ for LR or IR prostate cancer patients. HR patients are a very heterogeneous group, and excellent results can still be achieved for HR patients with only one HR feature.
Written by:
Vargas C, Swartz D, Vashi A, Blasser M, Kasareian A, Cesaretti J, Kiley K, Terk M. Are you the author?
Florida Center for Prostate Care, Jacksonville, FL.
Reference: Brachytherapy. 2012 Oct 9. pii: S1538-4721(12)00210-3.
doi: 10.1016/j.brachy.2012.08.002
PubMed Abstract
PMID: 23062705
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