Free to total PSA ratios are commonly used as an adjunct to total PSA levels to better define an individual's risk for prostate cancer; however, its strengths and weaknesses are not well understood.
This article illustrates the use of likelihood ratios that can be generated from the reported sensitivities and specificities from given free to total PSA thresholds in either increasing or decreasing an individual patient's probability of prostate cancer. Understanding the strengths and limitations of free to total PSA testing will help clinicians anticipate whether its use is indicated or not.
Written by:
Yi Y, Breau RH, Witiuk K, Neuberger MM, Dahm P. Are you the author?
Department of Urology, University of Florida, College of Medicine, Gainesville, FL, USA; Division of Urology, Department of Surgery, University of Ottawa Ottawa Hospital Research Institute, Ottawa, ON, Canada; International Evidence Based Urology Working Group, Gainesville, FL, USA.
Reference: BJU Int. 2012 Oct 29. Epub ahead of print.
doi: 10.1111/j.1464-410X.2012.11446.x
PubMed Abstract
PMID: 23106827
UroToday.com Prostate Cancer Section
