Androgen deprivation therapy (ADT) for prostate cancer (PCa) has side effects that significantly impair health-related quality of life (HRQOL).
Exercise ameliorates many side effects of ADT but different modalities, particularly in the home-based setting, have not been well-studied. In this study we randomly assigned 66 PCa survivors receiving ADT to 6 months of home-based aerobic or resistance training. Psychosocial wellbeing and physical fitness were measured at baseline, 3 and 6 months, and then 6 months post-intervention. Intention-to-treat analyses showed that fatigue and HRQOL were not significantly different between groups; however, in a per-protocol analysis the resistance exercise training group demonstrated clinically significant improvements in HRQOL. Differential within-groups effects on physical fitness were also observed at various time-points. At all time-points, the aerobic training group engaged in significantly more physical activity than the resistance training group; a finding that should be further examined given evidence-based guidelines for activity volume in cancer survivors.
Written by:
Santa Mina D, Alibhai S MH, Matthew AG, Guglietti CL, Pirbaglou M, Trachtenberg J, Ritvo P. Are you the author?
Kinesiology Program, University of Guelph-Humber, Toronto, the Department of Surgical Oncology, Princess Margaret Hospital, Toronto; and the School of Kinesiology and Health Science, York University, Toronto, Ontario.
Reference: J Aging Phys Act. 2012 Dec 10. Epub ahead of print.
PubMed Abstract
PMID: 23238110
UroToday.com Prostate Cancer Section
