PURPOSE: To determine, with histopathological findings of radical prostatectomy as reference, whether diffusion-weighted imaging (DWI) using b = 2000 s/mm2 for 3-T magnetic resonance imaging (MRI) is superior to the use of b = 1000 s/mm2 for prostate cancer detection.
MATERIALS AND METHODS: This study evaluated 73 patients with biopsy-proven prostate cancer. All patients underwent preoperative 3-T MRI using T2-weighted imaging (T2WI) and DWI (b = 0, 1000, 2000 s/mm2 ). The following three sets of images were evaluated separately by two radiologists: protocol A (T2WI alone), protocol B (T2WI and DWI with b = 1000 s/mm2 ), and protocol C (T2WI and DWI with b = 2000 s/mm2 ). For estimation of diagnostic capability, area under the receiver operating characteristic (ROC) curve (AUC) was calculated.
RESULTS: A total of 341 cancer foci were found in the prostectomy specimens of 73 patients. Reader 1 rated AUCs of the three sets as; A 0.66, B 0.77, C 0.80. ROC analysis showed significant differences among the three protocols (A vs. B vs. C: P < 0.0001, A vs. B: P < 0.0001, B vs. C: P < 0.0001).
CONCLUSION: The use of b = 2000 s/mm2 for DWI with 3-T MRI is diagnostically superior to that of b = 1000 s/mm2 for prostate cancer detection.
Written by:
Ueno Y, Kitajima K, Sugimura K, Kawakami F, Miyake H, Obara M, Takahashi S. Are you the author?
Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Reference: J Magn Reson Imaging. 2013 Jan 4. Epub ahead of print.
doi: 10.1002/jmri.23953
PubMed Abstract
PMID: 23292979
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