A rapid, simple and specific cancer cell counting sensor would allow for early detection and better disease management.
We have developed a novel cell counting device that can specifically count 125 prostate cancer cells in both complex media with serum and a mixed cell population containing non-target cells within 15 min. The microfabricated glass chip with exposed gold apertures utilizes the anti-EpCAM antibody to selectively count prostate cancer cells via differential pulse voltammetry. The newly developed sensor exhibits excellent sensitivity and selectivity. The cells remain viable throughout the counting process and can be used for further analysis. This device could have utility for future applications in early stage cancer diagnosis.
Written by:
Moscovici M, Bhimji A, Kelley SO. Are you the author?
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada M5S 3M2.
Reference: Lab Chip. 2013 Feb 5;13(5):940-6.
doi: 10.1039/C2LC41049D
PubMed Abstract
PMID: 23334685
UroToday.com Prostate Cancer Section
