OBJECTIVES: To make the first analysis of the salvage radiotherapy outcomes for biochemical recurrence of prostate cancer after radical prostatectomy in African descendant people, witch has no healthcare access difficulties: the French West-Indies African-Caribbean people of Guadeloupe.
PATIENTS AND METHOD: Ninety successive patients, with biological failure after radical prostatectomies were treated in the University Hospital of Pointe-à-Pitre with salvage radiotherapy between April 2003 and December 2008. The retrospective study analysed the biochemical disease free survival (bDFs) after irradiation with Kaplan-Meier method, and the independent predictors of bDFs using the Cox model, with P< 0.05. The treatment failure was defined for PSA superior or equal to nadir +0.1ng/mL.
RESULTS: The median dose was 64Gy. At the median follow-up of 24.63months, 35 (38.9%) patients had biochemical recurrence. The median bDFs was 55.3months, the bDFs probabilities at months 12, 24, 36 and 48 were 8.1%, 70.3%, 61.9% and 56.1%. Multivariate analysis determined that the independents predictors of treatment failure were the seminals vesicles invasion (P=0.0094, Hazard ratio=2.63 CI 95%: [1.28-5.55]), the PSA velocity superior or equal to 0.75ng/mL per year (P=0.0002, Hazard ratio=3.88 CI95%: [1.86-7.75]) and the pre-irradiation PSA level superior or equal to 1.5ng/mL (P=0.0093, Hazard ratio=2.89 CI95%: [1.30-6.45]).
CONCLUSION: Salvage radiotherapy for African descendent people with no healthcare difficulty access was an efficient treatment for the biochemical recurrence and had the same outcomes than others Caucasian people.
Written by:
Agoua NG, Vian E, Dumoulin M, Blanchet P. Are you the author?
Service d'urologie, CHU de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe.
Reference: Prog Urol. 2013 Feb;23(2):128-36.
doi: 10.1016/j.purol.2012.09.007
PubMed Abstract
PMID: 23352306
Article in French.
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