We investigated whether statin use is associated with reduced risk of recurrence in prostate cancer patients who undergo radiotherapy.
A retrospective cohort of 774 patients from a California health plan was followed for 5years. Statin use prior to, during and after radiotherapy was not associated with prostate cancer recurrence [hazard ratio=0.99 (0.70-1.39), 0.87 (0.62-1.22) and 0.78 (0.55-1.09), respectively] in multivariable Cox models. No clear dose-response relationship was observed for average daily statin dose or duration of statin use. Our findings do not support a preventive benefit of statins in prostate cancer recurrence after radiotherapy.
Written by:
Chao C, Williams SG, Xu L, Chen J, Wallner LP, Porter KR, Jacobsen SJ. Are you the author?
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA.
Reference: Cancer Lett. 2013 Feb 16. pii: S0304-3835(13)00129-8.
doi: 10.1016/j.canlet.2013.02.017
PubMed Abstract
PMID: 23419526
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