We examine the quality of plans created using multicriteria optimization (MCO) treatment planning in intensity-modulated radiation therapy (IMRT) in treatment of localized prostate cancer.
Nine random cases of patients receiving IMRT to the prostate were selected. Each case was associated with a clinically approved plan created using Corvus. The cases were replanned using MCO-based planning in RayStation. Dose-volume histogram data from both planning systems were presented to 2 radiation oncologists in a blinded evaluation, and were compared at a number of dose-volume points. Both physicians rated all 9 MCO plans as superior to the clinically approved plans (p< 10-5). Target coverage was equivalent (p = 0.81). Maximum doses to the prostate and bladder and the V50 and V70 to the anterior rectum were reduced in all MCO plans (p< 0.05). Treatment planning time with MCO took approximately 60 minutes per case. MCO-based planning for prostate IMRT is efficient and produces high-quality plans with good target homogeneity and sparing of the anterior rectum, bladder, and femoral heads, without sacrificing target coverage.
Written by:
Wala J, Craft D, Paly J, Zietman A, Efstathiou J. Are you the author?
Harvard Medical School, Boston, MA; Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA.
Reference: Med Dosim. 2013 Mar 26. pii: S0958-3947(13)00021-6.
doi: 10.1016/j.meddos.2013.02.012
PubMed Abstract
PMID: 23540492
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