PURPOSE: Recurrent prostate cancer is usually treated by combining radiotherapy and androgen deprivation therapy.
To stage the cancer, choline positron emission tomography (PET)/CT can be performed. It is generally thought that androgen deprivation therapy does not influence choline PET/CT. In this article we focus on the molecular backgrounds of choline and androgens, and the results of preclinical and clinical studies performed using PET/CT.
METHODS: Using PubMed, we looked for the relevant articles about androgen deprivation therapy and choline PET/CT.
RESULTS: During ADT, a tendency of decreased uptake of choline in prostate cancer was observed, in particular in hormone-naïve patients.
CONCLUSION: We conclude that in order to prevent false-negative choline PET/CT scans androgen deprivation should be withheld prior to scanning, especially in hormone-naïve patients.
Written by:
Dost RJ, Glaudemans AW, Breeuwsma AJ, de Jong IJ. Are you the author?
Department of Urology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Reference: Eur J Nucl Med Mol Imaging. 2013 Apr 6. Epub ahead of print.
doi: 10.1007/s00259-013-2398-7
PubMed Abstract
PMID: 23564037
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