Purpose: To compare Partin tables (PTs) 1997, 2001, and 2007 for their clinical applicability in a Chinese cohort based upon a decision curve analysis (DCA).
Methods: Clinical and pathologic data of 264 consecutive Chinese patients with clinically localized prostate cancer were used. These patients underwent open radical prostatectomy between 2005 and 2011. DCA quantified the net benefit of different PT versions relating to specific threshold probabilities of established capsular penetration (ECP), seminal vesicle involvement (SVI), and lymph node involvement (LNI).
Results: Overall, ECP, SVI, and LNI were recorded in 23.1, 10.2, and 6.1%, respectively. When the threshold probability was below the prevalence for LNI and ECP predictions, the DCA favored the 2007 version versus the 1997 version for SVI.
Conclusions: DCA indicates that for low threshold probability, decision models are useful to discriminate the performance differences of three PT versions, although net benefit differences were not apparent. For high threshold probability, there may not be an important benefit from the use of PTs and the current analysis cannot translate into meaningful net gains differences.
Written by:
Xiao WJ, Ye DW, Yao XD, Zhang SL, Dai B. Are you the author?
Department of Urology, Fudan University Shanghai Cancer Centre, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Reference: Urol Int. 2013 Mar 28. Epub ahead of print.
doi: 10.1159/000347186
PubMed Abstract
PMID: 23548872
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