BACKGROUND AND PURPOSE: Biological dose escalation through stereotactic ablative radiotherapy (SABR) holds promise of improved patient convenience, system capacity and tumor control with decreased cost and side effects.
The objectives are to report the toxicities, biochemical and pathologic outcomes of this prospective study.
MATERIALS AND METHODS: A phase I/II study was performed where low risk localized prostate cancer received SABR 35Gy in 5 fractions, once weekly on standard linear accelerators. Common Terminology Criteria for Adverse Events v3.0 and Radiation Therapy Oncology Group late morbidity scores were used to assess acute and late toxicities, respectively. Biochemical control (BC) was defined by the Phoenix definition.
RESULTS: As of May 2012, 84 patients have completed treatment with a median follow-up of 55months (range 13-68months). Median age was 67years and median PSA was 5.3ng/ml. The following toxicities were observed: acute grade 3+: 0% gastrointestinal (GI), 1% genitourinary (GU), 0% fatigue; late grade 3+: 1% GI, 1% GU. Ninety-six percent were biopsy negative post-treatment. The 5-year BC was 98%.
CONCLUSIONS: This novel technique employing standard linear accelerators to deliver an extreme hypofractionated schedule of radiotherapy is feasible, well tolerated and shows excellent pathologic and biochemical control.
Written by:
Loblaw A, Cheung P, D'Alimonte L, Deabreu A, Mamedov A, Zhang L, Tang C, Quon H, Jain S, Pang G, Nam R. Are you the author?
Department of Radiation Oncology, University of Toronto, Canada; Department of Health Policy, Measurement and Evaluation, University of Toronto, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Western Australia, Australia.
Reference: Radiother Oncol. 2013 May 3. pii: S0167-8140(13)00151-5.
doi: 10.1016/j.radonc.2013.03.022
PubMed Abstract
PMID: 23647750
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