Aim: To report the acute toxicity of a hypofractionated regimen of intensity-modulated radiotherapy with simultaneous integrated boost (SIB-IMRT) to the pelvic nodes and the prostatic bed after radical prostatectomy.
PATIENTS AND METHODS: Patients with prostate adenocarcinoma at high risk of relapse after radical prostatectomy or with biochemical relapse were deemed eligible for study. SIB-IMRT was prescribed to the whole pelvis (45-Gy delivered in 1.8-Gy fractions) and the prostatic bed [62.5 Gy, 2.5-Gy fractions, Equivalent Dose in 2-Gy fraction (EQD2)=68.75 Gy, α/β=3]. Acute toxicity was recorded and graded according to Radiation Therapy Oncology Group (RTOG) criteria.
RESULTS: Forty-nine patients were enrolled. No cases of grade ≥3 acute toxicity were recorded. Grade 2 acute genitourinary and gastrointestinal toxicity was observed in 9.6% and 29.7% of patients, respectively.
CONCLUSION: After radical prostatectomy, hypofractionated high-dose SIB-IMRT enables for reduction of the overall treatment time, with an acute toxicity profile which compares favourably with that of conventionally fractionated high-dose three-dimensional conformal radiotherapy (3D-CRT).
Written by:
Massaccesi M, Cilla S, Deodato F, Digesù C, Macchia G, Caravatta L, Ippolito E, Picardi V, Ferro M, Mignogna S, Mattiucci GC, Valentini V, Piermattei A, Morganti AG. Are you the author?
Radiation Oncology Unit, Fondazione di Ricerca e Cura "Giovanni Paolo II", Università Cattolica del S. Cuore, Largo A. Gemelli 1, 86100 Campobasso, Italy.
Reference: Anticancer Res. 2013 Jun;33(6):2785-9.
PubMed Abstract
PMID: 23749942
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