OBJECTIVE: To analyze the correlations among comorbidity and overall survival (OS), biochemical progression-free survival (b-PFS) and toxicity in elderly patients with localized prostate cancer treated with 125I brachytherapy.
METHODS: Elderly men, aged ≥65 years, with low-intermediate risk prostate cancer, were treated with permanent 125I brachytherapy as monotherapy. Comorbidity data were obtained from medical reports using age-adjusted Charlson comorbidity index (a-CCI). The patients were categorized into two age groups (< 75 and ≥75 years old), and two comorbidity score groups (a-CCI ≤ 3 and >3). Toxicity was scored with Radiation Therapy Oncology Group (RTOG) scale.
RESULTS: From June 2003 to October 2009, a total of 92 elderly patients underwent prostate brachytherapy, including 57 men (62%) with low-risk prostate cancer, and 35 men (38%) with intermediate-risk prostate cancer. The median age of patients was 75 years (range, 65-87 years). Forty-seven patients (51%) had a-CCI ≤ 3 and 45 patients (49%) a-CCI >3. With a median follow-up period of 56 months (range, 24-103 months), the 5-year actuarial OS and b-PFS were 91.3% and 92.4% respectively, without statistical significance between two Charlson score groups. Toxicity was mild. None of the patients experienced gastrointestinal (GI) toxicity, and only 4 patiens (4%) experienced late genitourinary (GU) grade-3 (G3) toxicity. No correlation between acute GU and GI toxicity and comorbidity was showed (P=0.50 and P=0.70, respectively).
CONCLUSIONS: Our data suggest that elderly men with low-intermediate risk prostate cancer and comorbidity can be considered for a radical treatment as 125I low-dose rate brachytherapy.
Written by:
Chiumento C, Fiorentino A, Cozzolino M, Caivano R, Clemente S, Pedicini P, Fusco V. Are you the author?
Department of Radiation Oncology, IRCCS-CROB, Rionero in Vulture 85028, Italy.
Reference: Chin J Cancer Res. 2013 Jun;25(3):274-80.
doi: 10.3978/j.issn.1000-9604.2013.06.06
PubMed Abstract
PMID: 23825903
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