Aim: To evaluate the relationship between Prostate cancer gene 3 (PCA3) score and prostate cancer as assessed by Gleason Score (GS) and pathological stage in a series of Italian patients, with elevated Prostate specific antigen (PSA) undergoing radical prostatectomy (RP).
PATIENTS AND METHODS: A total of 222 patients underwent RP for clinically localized prostate cancer; total PSA, free-PSA (%fPSA) and PCA3 score were collected and the possible associations among PCA3 and histological grade/pathological stage at biopsy and RP were investigated.
RESULTS: Median PCA3 scores by GS at radical prostatectomy were 51 vs. 67 (GS < 7 vs. GS ≥7, p=0.007), while scores at the biopsy were 56 vs. 67 (GS < 7 vs. GS ≥7, p=0.007), and in pT2 vs. pT3 patients they were 54 vs. 80 (p=0.001). Positive digital rectal examination (DRE) (odds ratio (OR)=5.47, p=0.026), pT3 pathological stage (OR=3.68, p=0.006) and PCA3≥35 (OR=2.04, p=0.030) were the main risk factors for the presence of an aggressive disease (GS≥7 at RP).
CONCLUSION: PCA3 score could play an interesting role in predicting significant disease: positive DRE (OR=5.47, p=0.026), pT3 pathological stage (OR=3.68, p=0.006) and PCA3≥35 (OR=2.04, p=0.030) were the main independent risk factors for GS≥7 at RP.
Written by:
DE Luca S, Passera R, Bollito E, Milillo A, Scarpa RM, Papotti M, Coda R, Randone DF. Are you the author?
Division of Urology, Ospedale Gradenigo, Corso Regina Margherita 8, 10153, Torino, Italy.
Reference: Anticancer Res. 2013 Oct;33(10):4657-62.
PubMed Abstract
PMID: 24123045
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