BACKGROUND/AIM: To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer.
PATIENTS AND METHODS: In 95 patients irradiated with 10×3 Gy for MSCC from prostate cancer, seven factors were investigated: Age, performance score, number of involved vertebrae, interval from prostate cancer diagnosis to MSCC, pre-radiotherapy ambulatory status, time to motor deficits development, number of involved extra-spinal organs.
RESULTS: Six-month survival rates for 0, 1 and ≥2 involved extra-spinal organs, were 81, 53 and 33%, respectively (p< 0.001). On multivariate analysis, the number of involved extra-spinal organs maintained significance (risk ratio 1.88, p=0.023). Better performance score (p< 0.001), longer interval from prostate cancer diagnosis to radiotherapy of MSCC (p< 0.001), and being ambulatory prior to radiotherapy (p=0.001) were also positively associated with survival.
CONCLUSION: The number of extra-spinal organs involved by metastases predicts survival in patients with MSCC from prostate cancer.
Written by:
Weber A, Bartscht T, Karstens JH, Schild SE, Rades D. Are you the author?
Department of Radiation Oncology, University of Lübeck, Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.
Reference: Anticancer Res. 2013 Oct;33(10):4505-7.
PubMed Abstract
PMID: 24123022
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