PURPOSE: Men with prostate cancer receiving androgen deprivation therapy (ADT) are at increased risk for decreased bone mineral density (BMD).
This study evaluates the relationship between self-reported daily activity, endurance and resistance exercise, and BMD measured by dual-energy x-ray absorptiometry (DEXA) in prostate cancer patients receiving ADT.
DATA SOURCES: We recruited 96 men treated with ADT for ≥9 months from urology and cancer practices. The Canadian Fitness Survey assessed daily activity and exercise. Data on demographic and lifestyle characteristics and calcium and vitamin D supplementation were collected. Blood was collected for analysis of 25-OH vitamin D. A DEXA scan was performed.
CONCLUSIONS: A positive association between endurance exercise and DEXA T-scores of the hip was shown. Regression analysis showed endurance exercise of medium to heavy intensity (measured as energy expenditure in MET-hours/week) was associated with T-scores of the hip (β = 0.048; 95% CI 0.003, 0.112; p = .040) but not with spinal T-scores after controlling for age, body mass index, and alcohol use.
IMPLICATIONS FOR PRACTICE: Findings are cross-sectional, but if confirmed in prospective studies suggest that increased endurance exercise is a practical measure nurse practitioners can institute to prevent low bone density in the hip of men treated with ADT.
Written by:
Mennen-Winchell LJ, Grigoriev V, Alpert P, Dos Santos H, Tonstad S. Are you the author?
University Medical Center of Southern Nevada, Las Vegas, Nevada.
Reference: J Am Assoc Nurse Pract. 2013 Aug 27. Epub ahead of print.
doi: 10.1002/2327-6924.12066
PubMed Abstract
PMID: 24170604
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