RATIONALE AND OBJECTIVES: To investigate the relationship between apparent diffusion coefficient (ADC) values and the Ki-67 staining index (Ki-67 SI), a tumor proliferation marker, in prostate cancer (PCa).
MATERIALS AND METHODS: Forty-three patients with PCa and thirty-six patients with benign prostatic hyperplasia (BPH) underwent diffusion-weighted (DW) imaging on 3T magnetic resonance (MR) with pelvic phased-array coil. The ADC values of PCa were calculated from two DW images (b = 0, 800 s/mm2). Immunohistochemical staining for Ki-67 was used to determine the Ki-67 SI of PCa and BPH. The Pearson correlation test was used to examine the relationship between ADC values and the Ki-67 SI. The ADC values of PCa with different level of Ki-67 SI were compared using an independent-sample t-test.
RESULTS: The mean (±standard deviation [SD]) Ki-67 SI of PCa (7.23 ± 5.29%) was higher than that of BPH (2.11 ± 1.90%) (P < .001). The mean (±SD) ADC value (10-3 mm2/s) of PCa (0.850 ± 0.155) was lower than that of BPH (1.173 ± 0.245) (P < .001). The ADC values of PCa were negatively correlated with the Ki-67 SI (r = -0.459, P = .002). The mean ADC values of PCa with Ki-67 >3.5% and ≤ 3.5% were (0.803 ± 0.094) and (0.936 ± 0.208), respectively. The former was significantly lower than the latter (P = .031). The ADC values of PCa with Ki-67 >7.1% and ≤ 7.1% were (0.779 ± 0.081) and (0.906 ± 0.178), respectively. The difference was significant (P = .004).
CONCLUSION: The ADC values of PCa could reflect the tumor proliferative activity and the differentiated degree of PCa.
Written by:
Zhang J, Jing H, Han X, Huang Z, Cao Z, Liu Q. Are you the author?
Department of Radiology, Shandong Provincial Hospital, Shandong University, No. 324, Jingwu Weiqi Road, Jinan, P. R. China 250021.
Reference: Acad Radiol. 2013 Dec;20(12):1535-41.
doi: 10.1016/j.acra.2013.09.007
PubMed Abstract
PMID: 24200480
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