OBJECTIVE: To evaluate the risk of prostate and bladder cancers in patients with spinal cord injury (SCI).
MATERIALS AND METHODS: We used data obtained from the National Health Insurance system of Taiwan for this study. The SCI cohort contained 54,401 patients with SCI, and each patient was randomly frequency matched with 4 people from the general population (without SCI) based on age, sex, and index date. Incidence rates, SCI cohort to non-SCI cohort rate ratios, and hazard ratios were measured to evaluate the cancer risks.
RESULTS: Patients with SCI showed a significantly lower risk of developing prostate cancer compared with subjects without SCI (adjusted hazard ratio = 0.73; 95% confidence interval = 0.59, 0.90), after accounting for the competing risk of death. No significant difference in the risk of bladder cancer emerged between the SCI and control groups. Further analyses found a higher spinal level of SCI tended to predict a lower risk for prostate cancer.
CONCLUSIONS: Patients with SCI incurred a lower risk for prostate cancer compared with people without SCI. The risk for bladder cancer did not differ between people with or without SCI.
Written by:
Lee WY, Sun LM, Lin CL, Liang JA, Chang YJ, Sung FC, Kao CH. Are you the author?
China Medical University Hospital Taipei Branch, Taipei, Taiwan; Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Reference: Urol Oncol. 2013 Nov 13. pii: S1078-1439(13)00310-4.
doi: 10.1016/j.urolonc.2013.07.019
PubMed Abstract
PMID: 24239459
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