PURPOSE: Improved diagnostic sensitivity could be obtained in cancer detection and staging when individual compounds of the choline pool can be detected. Therefore, a novel coil design is proposed, providing the ability to acquire both 1 H and 31 P magnetic resonance spectroscopic imaging (MRSI) in patients with prostate cancer.
METHODS: A two-element 1 H/31 P endorectal coil was designed by adjusting a commercially available 3T endorectal coil. The two-element coil setup was interfaced as a transceiver to a whole body 7T MR scanner. Simulations and phantom measurements were performed to compare the efficiency of the coil. 1 H MRSI and 31 P MRSI were acquired in vivo in prostate cancer patients.
RESULTS: The efficiency of the 1 H/31 P coil is comparable to the dual channel 1 H coil previously published. Individually distinguishable phospholipid metabolites in the in vivo 31 P spectra were: phosphoethanolamine, phosphocholine, phosphate, glycerophosphoethanolamine, glycerophosphocholine, phosphocreatine, and adenosine triposphate. 1 H MRSI was performed within the same scan session, visualizing choline, polyamines, creatine, and citrate.
CONCLUSION: 1 H MRSI and 31 P MRSI can be acquired in the human prostate at 7T within the same scan session using an endorectal coil matched and tuned for 1 H (quadrature) and 31 P (linear) without the need of cable traps and with negligible efficiency losses in the 1 H and 31 P channel.
Written by:
Luttje MP, Italiaander MG, Arteaga de Castro CS, van der Kemp WJ, Luijten PR, van Vulpen M, van der Heide UA, Klomp DW Are you the author?
Reference: BMagn Reson Med. 2013 Dec 19. (Epub ahead of print)
doi: 10.1002/mrm.25070.
PubMed Abstract
PMID: 24357271
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