The lack of dynamic dosimetry tools for permanent prostate brachytherapy causes otherwise avoidable problems in prostate cancer patient care. The goal of this work is to satisfy this need in a readily adoptable manner. Using the ubiquitous ultrasound scanner and mobile non-isocentric C-arm, we show that dynamic dosimetry is now possible with only the addition of an arbitrarily configured marker-based fiducial. Not only is the system easily configured from accessible hardware, but it is also simple and convenient, requiring little training from technicians. Furthermore, the proposed system is built upon robust algorithms of seed segmentation, fiducial detection, seed reconstruction, and image registration. All individual steps of the pipeline have been thoroughly tested, and the system as a whole has been validated on a study of 25 patients. The system has shown excellent results of accurately computing dose, and does so with minimal manual intervention, therefore showing promise for widespread adoption of dynamic dosimetry.
Written by:
Kuo N1, Dehghan E2, Deguet A3, Song DY4, Prince JL5, Lee J6 Are you the author?
1Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. 2Philips Research North America, Briarcliff Manor, NY, USA. 3Dept. of Computer Science, Johns Hopkins University, Baltimore, MD, USA. 4Dept. of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA. 5Dept. of Electrical and Computer Engineering, Johns Hopkins University, MD, USA. 6Dept. of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA ; Dept. of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
Reference: Proc SPIE. 2013 Mar 8;8671
doi: 10.1117/12.2008097
PubMed Abstract
PMID: 24392207
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