OBJECTIVE: To evaluate the spatial distribution of PCa detected at a single positive biopsy (PBx) and a repeat biopsy (rPBx).
MATERIALS AND METHODS: We evaluated 533 consecutive men diagnosed with PCa who underwent radical prostatectomy (RPE) using a cMDX-based map model of the prostate. We determined the number of cancer foci, relative tumour volume, Gleason score, zone of origin, localisation, and pathologic stage after stratification according to the number of biopsy sessions (PBx vs. rPBx). The distribution of 3,966 PCa foci was analysed and visualised on heat maps. The colour gradient of the heat map was reduced to 6 colours representing the frequency classification of PCa using an image posterisation effect. Additionally, the spatial distribution of organ-confined PCa between PBx and rPBx was evaluated.
RESULTS: PCa diagnosed on PBx was mostly localised to the apical portion and the peripheral zone (PZ) of the prostate. PCa diagnosed on rPBx was more frequently found in the anterior portion and the base of the prostate. Organ-confined PCa foci were mostly localised in the dorsolateral zone of the prostate in men with PBX, whereas men with rPBx had more PCa foci in the anterior portion of PCa.
CONCLUSIONS: The spatial distribution of PCa with rPBx differs significantly from the spatial distribution of PCa with PBx. The whole anterior portion of the prostate should be considered by rPBx.
Written by:
Eminaga O, Hinkelammert R, Abba M, Titze U, Eltze E, Bettendorf O, Wötzel F, Bögemann M, Semjonow A. Are you the author?
Dept. of Urology, University Hospital of Cologne, Kerpener Straße 62, D-50937 Cologne, Germany.
Reference: BJU Int. 2014 Feb 19. Epub ahead of print.
doi: 10.1111/bju.12691
PubMed Abstract
PMID: 24552505
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