Purpose: To assess the accuracy of endorectal 3 T magnetic resonance imaging (MRI) in detecting extracapsular extension (ECE) and seminal vesicle invasion (SVI) of prostate cancer (PCa).
Materials and Methods: 38 consecutive patients with biopsy-proven PCa underwent multiparametric endorectal MRI at 3 T prior to prostatectomy. Two readers (A with nine years of experience and B with four) used established criteria for ECE and SVI to diagnose the extent of local disease in six regions (apical, dorsolateral, basal; left and right each) with the highest chance of ECE. The standard of reference was provided by intraoperative frozen section analysis and prostatectomy specimens.
Results: Histopathology revealed ECE in 15 of the 222 regions (10 of 37 patients) and SVI in 8 of 74 potential regions (5 of 37 patients). The sensitivity, specificity, and accuracy in detecting ECE for reader A/B were 93 %/67 %, 92 %/95 % and 92 %/93 % per region and 90 %/80 %, 74 %/82 % and 78 %/81 % per patient, respectively. The corresponding values for the detection of SVI were 80 %/100 %, 96 %/99 % and 95 %/97 %, respectively.
Conclusion: Endorectal 3 T MRI is a highly reliable noninvasive technique for the local staging of PCa.
Written by:
Otto J, Thörmer G, Seiwerts M, Fuchs J, Garnov N, Franz T, Horn LC, Do MH, Stolzenburg JU, Kahn T, Moche M1, Busse H. Are you the author?
Department of Diagnostic and Interventional Radiology, Leipzig University Hospital; Department of Urology, Leipzig University Hospital; Institute of Pathology, University of Leipzig.
Reference: Rofo. 2014 Feb 20. Epub ahead of print.
doi: 10.1055/s-0033-1356186
PubMed Abstract
PMID: 24557601
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