This study aimed to evaluate the possibility of performing radical prostatectomy (RP) alone to achieve radical cure of prostate cancer in a high-risk group.
Between August 1998 and December 2008, 436 Japanese patients underwent antegrade RP following the exclusion of 139 patients. According to the D'Amico criteria, the low-, intermediate- and high-risk groups comprised 63, 122 and 112 patients, respectively. Twenty-five patients who were classified into the high-risk group based only on T2c stage, were evaluated as a separate intermediate/high-risk group. Results of the multivariate analysis revealed that of the preoperative characteristics only a biopsy Gleason score was a significant predictor in patients with and without PSA failure (P=0.017). After a median follow-up period of 60 months, the PSA failure-free rates in the low-, intermediate-, high- and intermediate/high-risk groups were 96.5, 92.2, 76.8 and 95.0%, respectively. No statistically significant difference was detected in the high- and intermediate/high-risk groups (P=0.064). Thus, patients classified into the high-risk group based on cT2 stage only, are considered to be potentially eligible for radical treatment by surgery alone, and should not be evaluated as high-risk patients.
Written by:
Furubayashi N, Nakamura M, Hishikawa K, Fukuda A, Matsumoto T, Nishiyama K, Yamanaka T, Hasegawa Y. Are you the author?
Departments of Urology, National Kyushu Cancer Center, Fukuoka, Japan; Pathology, National Kyushu Cancer Center, Fukuoka, Japan; Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan.
Reference: Mol Clin Oncol. 2013 Mar;1(2):337-342.
doi: 10.3892/mco.2012.39
PubMed Abstract
PMID: 24649172
UroToday.com Prostate Cancer Section
