Testosterone remains a key target in the treatment of advanced prostate cancer.
The relationship of free testosterone to prostate cancer treatment and outcomes remains largely unexplored. A consensus of prostate cancer experts was convened in 2013 to review current knowledge surrounding relationship of total and free testosterone to prostate cancer, discuss the free hormone hypothesis, and highlight future avenues for therapeutics. Free testosterone may better reflect prostate cancer tissue androgen levels than serum total testosterone concentration. Free testosterone deserves more research regarding its relation to clinical outcomes.
Written by:
Rove KO, Crawford ED, Perachino M, Morote J, Klotz L, Lange PH, Andriole GL, Matsumoto AM, Taneja SS, Eisenberger MA, Reis LO. Are you the author?
Division of Urology, University of Colorado, Anschutz Medical Campus, Aurora, CO; Ospedale Santo Spirito, Alessandria, Italy; Autónoma University of Barcelona, Barcelona, Spain; Sunnybrook Health Sciences Centre, Toronto, Canada; University of Washington, Seattle, WA; Washington University School of Medicine, St. Louis, MO; University of Washington/Veterans Affairs Puget Sound Health Care System, Seattle, WA; New York University School of Medicine, New York, NY; Johns Hopkins University School of Medicine, Baltimore, MD; University of Campinas, School of Medical Sciences, UNICAMP, Brazil.
Reference: Urology. 2014 Apr 5. pii: S0090-4295(14)00113-7.
doi: 10.1016/j.urology.2014.02.001
PubMed Abstract
PMID: 24713136
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