OBJECTIVE: To assess the incidence and age-related histopathological characteristics of incidentally diagnosed prostate cancer (PCa) from specimens obtained via radical cystoprostatectomy (RCP) for muscle-invasive bladder cancer.
PATIENTS AND METHODS: A retrospective review of the histopathological features of 2,424 male patients who underwent a RCP for bladder cancer was done at eight centers between January 1996 and June 2012. No patient had preoperative suspicion of PCa. Statistical analyses were performed in different age-related groups.
RESULTS: Overall, a PCa was diagnosed in 518 men (21.4%). Incidences varied significantly according to age (5.2% in those aged < 50 years to 30.5% in those aged >75 years, p< 0.001). The majority of prostate cancers were considered as "non-aggressive" that is to say organ-confined (≤ pT2) and well-differentiated (Gleason score < 7). TNM stage and proportion with a Gleason score of ≥7 were significantly greater in older patients (p < 0.001). Apart from age, there were no preoperative predictive factors for "non-aggressive" prostate-cancer status. At the end of the follow-up, only nine patients (1.7%) had biochemical recurrence of PCa, and no preoperative predictive factors were identified.
CONCLUSION: The rate of incidentally diagnosed PCa from RCP specimens is ∼20%, most of them being organ-confined and well-differentiated. The probability of having a "non-aggressive" PCa decreases in older men.
Written by:
Pignot G, Salomon L, Lebacle C, Neuzillet Y, Lunardi P, Rischmann P, Zerbib M, Champy C, Roupret M, Peyronnet B, Verhoest G, Murez T, Quintens H, Larré S, Houédé N, Compérat E, Soulié M, Pfister C. Are you the author?
Department of Urology, Bicetre Academic Hospital, Assistance Publique Hôpitaux de Paris, Paris XI University, 94270 Le Kremlin Bicêtre, France; Oncologic Committee of the French Association of Urology (CCAFU).
Reference: BJU Int. 2014 May 13. Epub ahead of print.
doi: 10.1111/bju.12803
PubMed Abstract
PMID: 24825727
UroToday.com Prostate Cancer Section
