BACKGROUND: To evaluate the diagnostic usefulness of the cytological study of the transport buffer in the diagnosis of prostate adenocarcinoma in transrectal core biopsies.
METHODS: A total of 256 consecutively biopsied patients have been included in the analysis, 100 of them diagnosed of prostate adenocarcinoma. The procedure included the cytological analysis of the transport buffer and conventional histology. Cytological evaluation was performed in a blind way by the same pathologist.
RESULTS: Overall sensitivity, specificity, and positive and negative predictive values to detect malignancy in the cytological slides were 54%, 98%, 94% and 76%, respectively. When restricted the analysis to cases with Gleason score higher than 8, sensitivity and negative predictive value increased to 85% and 97%, respectively. Similarly, when the analysis focused exclusively to cases with more than 5mm of cancer in the biopsy, sensitivity and positive predictive value increased to 66% and 96%, respectively.
CONCLUSIONS: This study shows that whilst specificity was maintained in 98%, sensitivity, and positive and negative predictive values significantly improved in high grade and high volume adenocarcinomas. Our findings confirm that the cytological study of the transport buffer may complement the histology in the diagnosis of prostate adenocarcinoma.
Written by:
López JI, Cáceres F, Pérez A, Caamaño V, Larrinaga G, Lecumberri D, Arruza A. Are you the author?
Departamento de Patología, Hospital Universitario de Cruces, Universidad del País Vasco (UPV/EHU), Baracaldo, España; Departamento de Urología, Hospital Universitario de Cruces, Universidad del País Vasco (UPV/EHU), Baracaldo, España; Departamento de Enfermería, Universidad del País Vasco (UPV/EHU), Leioa, España.
Reference: Actas Urol Esp. 2014 May 12. pii: S0210-4806(14)00034-5.
doi: 10.1016/j.acuro.2014.01.003
PubMed Abstract
PMID: 24832100
Article in English, Spanish.
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