PURPOSE: To evaluate the histological correlation between transuretral resection chips and biopsy cores within a population of patients who underwent resection of prostate (TURP) and prostate biopsies (BPx).
PATIENTS AND METHODS: Clinical and tumoral data of 77 patients who had both procedures simultaneously or with a slight delay were collected. According to the presence of prostate cancer (Pca), 4 groups were defined: group 1 (TURP and BPx negative), group 2 (TURP positive, BPx negative), group 3 (TURP negative, BPx positive), group 4 (TURP and BPx positive). Means and proportions were compared using Anova and χ2 test, respectively.
RESULTS: The patients were older in groups 3 and 4 (79 and 76 respectively, P=0.65). The PSA was higher in the groups 3 and 4 (64 and 55 ng/mL) than the groups 1 and 2 (10.6 et 16 respectively, P=0.23). The number of positive biopsy was higher in the group 4 than the group 3 (5.6 vs. 4.6, P< 0.0001), the chips were more invaded in the group 4 than the group 2 (41% vs. 11% P< 0.0001), the Gleason score at TURP was higher in the group 4 than the group 2 (7.5 vs. 6.2 P< 0.0001).
CONCLUSION: Our study underlines that the Pca of transition and peripheral zones seems to have distinct characteristics. When chips of TURP and BPx were both invaded, it was due to an aggressive cancer. The decision to explore the peripheral zone in the case of positive TURP must take clinical context into consideration.
Written by:
Mathieu R, Tibari Y, Verhoest G, Vincendeau S, Manunta A, Rioux-Leclercq N, Bensalah K. Are you the author?
Service d'urologie, CHU de Rennes, hôpital Pontchaillou, 2, rue Henri-Le-Guillou, 35000 Rennes, France; Service d'anatomocytopathologie, CHU de Rennes, 35042 Rennes, France.
Reference: Prog Urol. 2014 May;24(6):374-8.
doi: 10.1016/j.purol.2013.10.002
PubMed Abstract
PMID: 24821561
Article in French.
UroToday.com Prostate Cancer Section
